Lacidipine is indicated for the treatment of hypertension either alone or in combination with other antihypertensive agents, including ß-adrenoceptor antagonists, diuretics, and ACE-inhibitors.

Hypertension (Hight Blood Pressure)

Adults: Treatment for hypertension should be customized to the severity of the problem as well as the patient's  response.

The recommended starting dose is 2 mg, taken once a day. After enough time has passed for the entire pharmacological impact to occur, the dose may be increased to 4 mg (and then, if necessary, to 6 mg). This should not be less than 3 to 4 weeks in practice. Daily doses greater than 6 mg have not been proved to be more effective. Lacidipine tablets should be taken on a daily basis at the same time, preferably in the morning. Lacidipine treatment can be continued indefinitely.

Patients with hepatic impairment: Lacidipine is metabolized largely by the liver, therefore its bioavailability may be raised and its hypotensive impact boosted in patients with hepatic impairment. These individuals should be closely followed, and a dose reduction may be indicated in extreme situations.

Side effects associated with lacidipine are-

• Dizziness
• Headache
• Palpitations
• Abdominal pain
• Nausea
• Asthenia
• Edema
• Polyuria

Dizziness	Headache	Asthenia
Edema	Polyuria	Nausea

• Lacidipine should be used with caution in patients with pre-existing abnormalities in the activity of the SA and AV nodes.
• Lacidipine should be used with caution in patients with congenital or documented acquired QT prolongation. Lacidipine should also be used with caution in patients treated concomitantly with medications known to prolong the QT interval such as class I and III antiarrhythmics, tricyclic antidepressants, some antipsychotics, antibiotics (e.g. erythromycin) and some antihistamines (e.g. terfenadine).
• As with other calcium antagonists, lacidipine should be used with caution in patients with poor cardiac reserve.