Name | Miconazole |
Classes |
Antiinfective Agent Dermatological/Topical Agent Topical Antiinfective Agent Antifungal Agent Vaginal Preparation |
Diseases |
Infectious Disease Mouth Infection Throat Infection |
Bangla
Miconazole
Miconazole is an antifungal of the azole group. It is available as oral gel.
Miconazole is indicated for the oral treatment of Oropharyngeal candidiasis.
For oral administration: 1 measuring spoon (provided) is equivalent to 124 mg miconazole per 5 mL gel.
Oropharyngeal candidiasis:
Infants: 4-24 months: 1.25 mL (1/4 measuring spoon) of gel, applied four times a day after meals. Each dose should be divided into smaller portions and the gel should be applied to the affected area(s) with a clean finger. The gel should not be applied to the back of the throat due to possible choking. The gel should not be swallowed immediately, but kept in the mouth as long as possible.
Adults and children 2 years of age and older:
- 2.5 mL (1/2 measuring spoon) of gel, applied four times a day after meals.
- The gel should not be swallowed immediately, but kept in the mouth as long as possible.
- The treatment should be continued for at least a week after the symptoms have disappeared.
- For oral candidiasis, dental prostheses should be removed at night and brushed with the gel.
Miconazole can cause the following side effects-
- Dry mouth
- Taste disturbances (dysgeusia)
- Nausea
- vomiting
- diarrhea
- regurgitation
- Miconazole is a systemic antibiotic that inhibits the enzymes CYP2C9 and CYP3A4, which can extend the effects of warfarin. With the use of miconazole oral gel and warfarin at the same time, bleeding events have been observed, some of which have been fatal.
- During therapy with miconazole and other miconazole formulations, severe hypersensitivity responses such as anaphylaxis and angioedema have been described.
- It is advisable to monitor miconazole and phenytoin levels, if these two drugs are used concomitantly.
Contraindication
Contraindicated in patients hypersensitive to miconazole or other azole antibiotics, such as-
Coadministration of the drugs that are subject to metabolism by CYP3A4, such as-
Contraindicated in patients with severe liver dysfunction.