Medicine details
| Image |  |
| Name | Aldonist 25 |
| Dosage | Tablet |
| Generic Name | Eplerenone |
| Classes |
Cardiovascular Agent Diuretic Antihypertensive |
| Diseases |
Cardiovascular Disease Hypertension (High Blood Pressure) Stroke |
| Company | Unimed & Unihealth Manufacturers Ltd. |
Drug Package Details
| Strength | 25 mg |
| Storage Condition | |
| Origin Country | Bangladesh |
| Commercial Pack | 28 |
| Price per pack | ৳ 1,260.00 |
| Cost per pack | ৳ 1,108.80 |
| Package unit | 7 tabs strip |
| Price per unit | ৳ 45.00 |
| Cost per unit | ৳ 39.60 |
| Discount | 0 |
| Coupon | |
| Remarks |
Eplerenone
Eplerenone is a K+ sparing diuretic. It is a direct aldosterone antagonist. Eplerenone binds to the intracellular mineralocorticoid aldosterone receptor and blocks aldosterone from binding.
Eplerenone is an aldosterone antagonist indicated for:
- Improving survival of stable patients with LV systolic dysfunction (LVEF ≤40%) and CHF after an acute myocardial infarction.
- Hypertension, alone or combined with other agents.
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CHF Post-Myocardial infarction: Initiate treatment with 25 mg once daily. Titrate to maximum of 50 mg once daily within 4 weeks, as tolerated. Dose adjustments may be required based on potassium levels.
Hypertension: 50 mg once daily, alone or combined with other antihypertensive agents. For inadequate response, increase to 50 mg twice daily. Higher dosages are not recommended.
For all patients: Measure serum potassium before starting eplerenone and periodically thereafter.
CHF Post-MI: Most common adverse reactions are hyperkalemia and increased creatinine.
Hypertension:
- dizziness
- diarrhea
- coughing
- fatigue
- flu-like symptoms
Hyperkalemia is more likely in patients with impaired renal function and diabetics with proteinuria. Proper patient selection and monitoring, as well as the avoidance of certain concomitant medications, can help to reduce the risk.
Contraindication
- Contraindicated in patients hypersensitive to eplerenone.
- Concomitant administration of strong CYP3A4 inhibitors is contraindicated, such as-
For patients treated with hypertension:
concomitant administration of potassium supplements or potassium-sparing diuretics such as-
None known.
Contraindicated in all patients with:
- serum potassium >5.5 mEq/L at initiation
- creatinine clearance ≤30 mL/min
For patients treated for hypertension:
- type 2 diabetes with microalbuminuria
- serum creatinine >2.0 mg/dL in males or >1.8 mg/dL in females
- creatinine clearance <50 mL/min
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